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Sitravatinib, Multikinase inhibitor / Immuno-oncology agent, 25mg, CAS# 1123837-84-2

Sitravatinib, Multikinase inhibitor / Immuno-oncology agent, 25mg, CAS# 1123837-84-2

Defactinib, FAK inhibitor, 5mg, CAS# 1073154-85-4

Defactinib, FAK inhibitor, 5mg, CAS# 1073154-85-4

IPI-549, PI3Kγ inhibitor, 25mg, CAS# 1693758-51-8

$175.00
(S)-2-Amino-N-[1-[8-[2-(1-methylpyrazol-4-yl)ethynyl]-1-oxo-2-phenylisoquinolin-3-yl]ethyl]pyrazolo[1,5-a]pyrimidine-3-carboxamide Purity: >98% by HPLC NMR (conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-4827-25mg-EA
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IPI-549, PI3Kγ inhibitor, 25mg, CAS# 1693758-51-8 is available to buy in increments of 1

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IPI-549 is a potent and highly selective inhibitor of PI3K-g in both biochemical (IC50 = 16 nM) and cellular (IC50 = 12.2 nM) assays.1 Macrophage PI3K-g has been found to be a critical switch between immune stimulation and suppression.2 IPI-549 has been used to reshape tumor immune microenvironments and promote cytotoxic T-cell-mediated tumor regression. Resistance to immune checkpoint blockade in 4T1 and B16-GMCSF tumors was overcome when anti-PD-1 or anti-CTLA4 therapies were combined with PI3Kg inhibition via IPI-549.3 IPI-549 mono-treatment also resulted in tumor growth inhibition in several cancer cell lines.3 IPI-549 has also been shown to modulate P-glycoprotein-mediated multidrug resistance.4

CAS Number: 1693758-51-8

Manufacturer Part Number/SKU: 10-4827-25mg-EA

Tags: Focus Biomolecules