iCRT5, β-catenin inhibitor, 5mg, CAS# 18623-44-4
$57.00
4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1371-5mg-EA
iCRT5, β-catenin inhibitor, 5mg, CAS# 18623-44-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA selective CRT (β-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable.
CAS Number: 18623-44-4
Manufacturer Part Number/SKU: 10-1371-5mg-EA
Tags: Focus Biomolecules