ICRF-193, Topoisomerase II inhibitor, 1mg, CAS# 21416-88-6
$125.00
Meso-4,4’-(2,3-butanediyl)-bis(2,6-piperazinedione) Purity: >98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5056-1mg-EA
ICRF-193, Topoisomerase II inhibitor, 1mg, CAS# 21416-88-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
CAS Number: 21416-88-6
Manufacturer Part Number/SKU: 10-5056-1mg-EA
Tags: Focus Biomolecules