Icilin, TRPM8 inhibitor, 50mg, CAS# 36945-98-9
$245.00
3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1H-pyrimidin-2-one Purity: >98% by TLC [5% methanol in methylene chloride; Rf = 0.40] Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4380-50mg-EA
Icilin, TRPM8 inhibitor, 50mg, CAS# 36945-98-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsIcilin is an agonist of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50 = 0.36 µM for CRM1, rat orthologue of TRPM8).1 Agonist at TRPM8 (EC50 = 0.2 µM)2 and ANKTM1(TRPA1)3. Agonist effects require Ca2+ and are pH dependent.2,4 Icilin induced G1 arrest in PC-3 prostate cancer cells without cell death.5
CAS Number: 36945-98-9
Manufacturer Part Number/SKU: 10-4380-50mg-EA
Tags: Focus Biomolecules