Ibrutinib, BTK inhibitor, 50mg, CAS# 936563-96-1
$125.00
1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one Purity: 99% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4757-50mg-EA
Ibrutinib, BTK inhibitor, 50mg, CAS# 936563-96-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsIbrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase).5
CAS Number: 936563-96-1
Manufacturer Part Number/SKU: 10-4757-50mg-EA
Tags: Focus Biomolecules