iBAP-II, BAP1 deubiquitinase inhibitor, 5mg, CAS# 1013813-81-4
$85.00
4-(8-Nitro-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-yl)phenol Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4038-5mg-EA
iBAP-II, BAP1 deubiquitinase inhibitor, 5mg, CAS# 1013813-81-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibitor of the H2AK119 deubiquitinase BAP1 (IC50 = 0.092 µg/ml). It is selective for BAP1 over UCHL5, USP5,7,8, TNFAIP3-catalytic domain, USP2-catalytic domain, Otubain-1, and Ataxin3. iBAP-II disrupted the BAP1/ASXL3/BRD4 axis via induction of protein degradation of the ASXL3 scaffold protein in the small cell lung cancer lines NCI-H1963, NCI-H748, and NCI-H1882. It also suppressed expression of the master transcription factor ASCL1 in NCI-H1963 small cell lung cancer cells. iBAP-II significantly delayed disease progression in a small cell lung cancer xenograft mouse model.
CAS Number: 1013813-81-4
Manufacturer Part Number/SKU: 10-4038-5mg-EA
Tags: Focus Biomolecules