Homoharringtonine, Protein synthesis inhibitor, 25mg, CAS# 26833-87-4
$195.00
Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate Purity: 95% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3033-25mg-EA
Homoharringtonine, Protein synthesis inhibitor, 25mg, CAS# 26833-87-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA plant alkaloid, originally isolated from the Hainan plum yew, that binds to the large ribosomal subunit A-site, competing with aminoacyl-tRNA amino acid side chains, thereby inhibiting the initial elongation step of protein synthesis.1 It also binds to transcription factors NKRF (NF-κB repressing factor) and SP1, down-regulating the Myc pathway.2,3 Dramatically decreases global DNA 5-hydroxymethylcytosine levels via the SP1/TET1 axis.3 Induces apoptosis in tyrosine kinase inhibitor-resistant NSCLC cells4, and is a clinically useful agent for CML and AML5.
CAS Number: 26833-87-4
Manufacturer Part Number/SKU: 10-3033-25mg-EA
Tags: Focus Biomolecules