GSK2830371, WIP1 phosphatase inhibitor, 25mg, CAS# 1404456-53-6
$195.00
5-[[(5-Chloro-2-methylpyridin-3-yl)amino]methyl]-N-[(2S)-3-cyclopentyl-1-(cyclopropylamino)-1-oxopropan-2-yl]thiophene-2-carboxamide Purity: 97% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4180-25mg-EA
GSK2830371, WIP1 phosphatase inhibitor, 25mg, CAS# 1404456-53-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent allosteric inhibitor of WIP1 phosphatase (IC50 = 6 nM), a negative regulator of the DNA damage response.1 It displayed no inhibition of 21 other phosphatases. Active in xenograft model DoHH2 B-cell lymphoma. GSK2830371 in combination with MDM2 inhibitors has been shown to be efficacious in the treatment of various cancers including liver adenocarcinoma2, acute myeloid leukemia3, and breast4. It enhances phosphorylation of the tumor suppressor p53 leading to activation.5,6
CAS Number: 1404456-53-6
Manufacturer Part Number/SKU: 10-4180-25mg-EA
Tags: Focus Biomolecules