GSK2606414, PERK inhibitor, 5mg, CAS# 1337531-36-8
$65.00
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydroindol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethenone Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4716-5mg-EA
GSK2606414, PERK inhibitor, 5mg, CAS# 1337531-36-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent (IC50 = 0.4 nM) and selective (against a panel of 294 kinases) inhibitor of protein kinase R-like endoplasmic reticulum kinase (PERK), an important effector of the unfolded protein response (UPR).1 It prevented neurodegeneration in a mouse model of frontotemporal dementia2 and rodent models of Parkinsons disease via modulation of the UPR3. GSK2606414 has been reported to be a potent inhibitor of RIPK1 (IC50 = 18 nM).4 It has also displayed neuroprotective effects in various models of stroke.5-7
CAS Number: 1337531-36-8
Manufacturer Part Number/SKU: 10-4716-5mg-EA
Tags: Focus Biomolecules