Grapiprant, EP4 receptor antagonist., 5mg, CAS# 415903-37-6
$80.00
1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4006-5mg-EA
Grapiprant, EP4 receptor antagonist., 5mg, CAS# 415903-37-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsGrapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant anti-inflammatory effects in a rat model of adjuvant-induced arthritis.2 EP4 receptors have been shown to be involved in PGE2 stimulation of Th1 differentiation and Th17 expansion revealing a potential role for PGE2 receptors in immunosuppression.3,4 Grapiprant/Pembrolizumab combination is in clinical trials for advanced or metastatic NSCLC adenocarcinoma.5
CAS Number: 415903-37-6
Manufacturer Part Number/SKU: 10-4006-5mg-EA
Tags: Focus Biomolecules