GAT2711, α9 nAChR agonist, 25mg, CAS# N/A
$265.00
1-Ethyl-1-methyl-4-(4-(6-methylpicolinamido)phenyl)piperazin-1-ium Iodide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4330-25mg-EA
GAT2711, α9 nAChR agonist, 25mg, CAS# N/A is available to buy in increments of 1
Product Details
Download Details and SpecificationsGAT2711 is a novel full agonist of the α9 nicotinic acetylcholine receptor (EC50 = 230 nM; EC50 for α9α10 = 990 nM). It was 340-fold selective over the α7 receptor. GAT2711 significantly and dose-dependently inhibited the BzATP-induced release of the pro-inflammatory cytokine IL-1ß in THP-1 cells (IC50 = 0.5 µM). It fully attenuated inflammatory pain in mice in an α7 nAChR-independent manner. α9 nAChR agonists represent a novel approach to treating inflammatory and/or neuropathic pain.
Manufacturer Part Number/SKU: 10-4330-25mg-EA
Tags: Focus Biomolecules