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Lactose, Monohydrate, NF, EP, BP, JP, bioCERTIFIED(TM)), 25kg, CAS# 10039-26-6

Lactose, Monohydrate, NF, EP, BP, JP, bioCERTIFIED(TM)), 25kg, CAS# 10039-26-6

Nocardamine, Natural product siderophore, 1mg, CAS# 26605-16-3

Nocardamine, Natural product siderophore, 1mg, CAS# 26605-16-3

DS18561882, MTHFD2 inhibitor, 5mg, CAS# 2227149-22-4

$100.00
N-[4-[8-[(3S)-3,4-Dimethylpiperazin-1-yl]-7-methyl-5-oxo-2,4-dihydro-1H-chromeno[3,4-c]pyridine-3-carbonyl]-2-(trifluoromethoxy)phenyl]methanesulfonamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-4188-5mg-EA
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DS18561882, MTHFD2 inhibitor, 5mg, CAS# 2227149-22-4 is available to buy in increments of 1

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Potent (IC50 = 6.3 nM) and selective (>90-fold over MTHFD1) inhibitor of the mitochondrial enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a key enzyme in one carbon metabolism in purine or thymidine biosynthesis.1 It almost completely inhibited tumor growth in an MDA-MB-231 mouse xenograft model. DS18561882 treatment of triple-negative breast cancer cells lead to significant reduction of cancer cell proliferation but not apoptosis; however, in combination with Chk1 inhibitors it led to apoptotic cell death.2 In combination with enzalutamide, it significantly inhibited castration resistant prostate cancer cells in vitro and in vivo.3

CAS Number: 2227149-22-4

Manufacturer Part Number/SKU: 10-4188-5mg-EA

Tags: Focus Biomolecules