DRB, Transcription inhibitor, CK2 inhibitor, 10mg, CAS# 53-85-0
$35.00
5,6-Dichloro-1-ß-D-ribofuranosylbenzimidazole Purity: 98% by HPLC NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2047-10mg-EA
DRB, Transcription inhibitor, CK2 inhibitor, 10mg, CAS# 53-85-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 μM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 μM. 3 Suppresses the SIRT1/CK2α pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
CAS Number: 53-85-0
Manufacturer Part Number/SKU: 10-2047-10mg-EA
Tags: Focus Biomolecules