Deucravacitinib, Allosteric TYK2 inhibitor, 25mg, CAS# 1609392-27-9
$375.00
6-(Cyclopropanecarbonylamino)-4-[2-methoxy-3-(1-methyl-1,2,4-triazol-3-yl)anilino]-N-(trideuteriomethyl)pyridazine-3-carboxamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4756-25mg-EA
Deucravacitinib, Allosteric TYK2 inhibitor, 25mg, CAS# 1609392-27-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsDeucravacitinib is very potent and selective allosteric inhibitor of tyrosine kinase 2 (TYK2). It binds to and is selective for the TYK2 pseudokinase domain (JH2, IC50 = 0.2 nM), with no activity against canonical JH1 domain of TYK2, JAK1,2, or 3.1 It is 5-fold less active against the JAK1 JH2 domain (IC50 = 1 nM). Deucravacitinib blocked signaling and functional responses in human TH17, TH1, B cells, and myeloid cells and displayed robust efficacy in vitro and in vivo in autoimmune disease animal models.2
CAS Number: 1609392-27-9
Manufacturer Part Number/SKU: 10-4756-25mg-EA
Tags: Focus Biomolecules