Defactinib, FAK inhibitor, 5mg, CAS# 1073154-85-4
$65.00
N-Methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]aminl]benzamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4828-5mg-EA
Defactinib, FAK inhibitor, 5mg, CAS# 1073154-85-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsDefactinib (1073154-85-4) is a potent inhibitor of FAK (IC50 = 0.6nM) and Pyk2 (IC50 = 0.6nM).1 It is active in vivo (EC50 = 26nM). FAK inhibition prevents tumor invasion and dissemination rather than tumor size reduction. Defactinib has been shown to preferentially target cancer stem cells in a mouse xenograft model of triple negative breast cancer.2 It is in multiple clinical trials for various cancers3 and in shows synergistic activity when used in combination with checkpoint immunotherapy 4-6.
CAS Number: 1073154-85-4
Manufacturer Part Number/SKU: 10-4828-5mg-EA
Tags: Focus Biomolecules