DBIC, DNMT3B S-nitrosylation inhibitor, 25mg, CAS# 487026-67-5
$300.00
(E)-N’-(3,4-Dihydroxybenzylidene)-1H-benzo[d]imidazole-5-carbohydrazide Purity: >98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5161-25mg-EA
DBIC, DNMT3B S-nitrosylation inhibitor, 25mg, CAS# 487026-67-5 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSpecifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50≤100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat # 10-5162) is also available.
CAS Number: 487026-67-5
Manufacturer Part Number/SKU: 10-5161-25mg-EA
Tags: Focus Biomolecules