Dabrafenib, B-Raf mutant inhibitor, 5mg, CAS# 1195765-45-7
$40.00
N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-benzenesulfonamide Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1569-5mg-EA
Dabrafenib, B-Raf mutant inhibitor, 5mg, CAS# 1195765-45-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsDabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50 = 3.2 and 5 nM, respectively).1 Has been in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors. Endoplasmic reticulum stress and autophagy are induced in melanoma cells after treatment with dabrafenib and protect cells from dabrafenib toxicity.2 Induces epithelial differentiation in BRAF-mutant colorectal cancer cells.3
CAS Number: 1195765-45-7
Manufacturer Part Number/SKU: 10-1569-5mg-EA
Tags: Focus Biomolecules