CX-5461, RNA polymerase I inhibitor, 5mg, CAS# 1138549-36-6
$75.00
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-N-[(5-methyl-2-pyrazinyl)methyl]-5-oxo-5H-benzothiazolo [3,2-a][1,8]naphthyridine-6-carboxamide Purity: >98% by HPLC Purity: NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2998-5mg-EA
CX-5461, RNA polymerase I inhibitor, 5mg, CAS# 1138549-36-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsCX-5461 (1138549-36-6) is a first-in-class selective RNA polymerase I inhibitor, suppressing Pol I transcription in MV 4;11 myelomonocytic leukemia cells and SR immunoblastic lymphoma cells with EC50 values of 95 and 135 nM respectively and demonstrating 200-fold selectivity over Pol II.1,2 Activates the DNA damage response.3 It induces a rapid accumulation of cytosolic DNA which results in upregulation of STING.4 Acts as a potent immunosuppressant inhibiting T cell-mediated alloimmunity and representing a novel class of immunosuppressant.5
CAS Number: 1138549-36-6
Manufacturer Part Number/SKU: 10-2998-5mg-EA
Tags: Focus Biomolecules