CPI-455, Lysine demethylase KDM5 inhibitor, 25mg, CAS# 1628208-23-0
$325.00
7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile Purity: 98% by HPLC NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4035-25mg-EA
CPI-455, Lysine demethylase KDM5 inhibitor, 25mg, CAS# 1628208-23-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsCPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1 CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a dose-dependent, KDM5-dependent manner in multiple cell lines treated with standard chemotherapy or targeted agents. CPI-455 synergized with 5-aza-2'-deoxycytidine (DAC) to reduce the viability of luminal breast cancer cells in vitro.2 KDM5 demethylases have recently been shown to repress the immune response to tumors via suppression of STING.3
CAS Number: 1628208-23-0
Manufacturer Part Number/SKU: 10-4035-25mg-EA
Tags: Focus Biomolecules