CCT251236, HSF stress pathway inhibitor, 5mg, CAS# 1693731-40-6
$90.00
N-[5-(2,3-Dihydro-1,4-benzodioxine-6-carbonylamino)-2-methylphenyl]-2-(2-pyrrolidin-1-ylethoxy)quinoline-6-carboxamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4410-5mg-EA
CCT251236, HSF stress pathway inhibitor, 5mg, CAS# 1693731-40-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibitor of the Heat Shock Transcription Factor 1 (HSF1) stress pathway (IC50 = 19 nM Inhibition HSF-1 mediated HSP72 induction, IC50 = 40 nM HSPA1A induction).1 It displayed efficacy in a human ovarian carcinoma xenograft mouse model (SK-OV 3 cells) and inhibited migration of WM266.4 melanoma cells @ 100 nM. CCT251236 showed high affinity for the protein pirin (Ki = 28 nM), but this target was not shown conclusively to be the cause of the anticancer activity. It also showed efficacy in vitro against primary patient-derived myeloma cells and H929 human myeloma xenograft models.2
CAS Number: 1693731-40-6
Manufacturer Part Number/SKU: 10-4410-5mg-EA
Tags: Focus Biomolecules