CB-839, Glutaminase inhibitor, 5mg, CAS# 1439399-58-2
$55.00
Purity: 0.8 mL/min Purity: 245 and 270 nm. NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4556-5mg-EA
CB-839, Glutaminase inhibitor, 5mg, CAS# 1439399-58-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsCB-839 is a potent (IC50 = 24 nM), selective and orally bioavailable inhibitor of glutaminase (KGA and GAC).1 CB-839 displayed an antiproliferative effect in the triple-negative breast cancer cell line, HCC-1806, but no activity in the estrogen receptor-positive cell line T47D. CB-839 was able to cause proliferation arrest and apoptosis in acute myeloid leukemia cells without causing cytotoxicity against normal human CD34(+) progenitors.2 Aspartate-glutamate carrier 1 (AGC1) inhibition can synergize with CB-839 to limit tumor growth.3
CAS Number: 1439399-58-2
Manufacturer Part Number/SKU: 10-4556-5mg-EA
Tags: Focus Biomolecules