Cabozantinib, Met and VEGFR2 inhibitor, 25mg, CAS# 849217-68-1
$150.00
N-(4-((6,7-Dimethoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3231-25mg-EA
Cabozantinib, Met and VEGFR2 inhibitor, 25mg, CAS# 849217-68-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsNovel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM respectively. In cellular assays it inhibits the following kinases: MET, VEGF2, KIT, FLT3 and AXL, IC50=7.8, 1.9, 5.0, 7.5 and 42 μM respectively.1 Eliminated approximately 80% of vasculature in spontaneous pancreatic islet tumors over 7 days in a mouse model.2 Clinically useful anticancer agent.3
CAS Number: 849217-68-1
Manufacturer Part Number/SKU: 10-3231-25mg-EA
Tags: Focus Biomolecules