Bosutinib, Dual Src/Abl kinase inhibitor, 5mg, CAS# 380843-75-4
$40.00
4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile Purity: >98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2122-5mg-EA
Bosutinib, Dual Src/Abl kinase inhibitor, 5mg, CAS# 380843-75-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAn ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM).1 It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR.2 Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants.3 Enhances retinoic acid-induced differentiation of HL-60 leukemia cells.4 Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells).5
CAS Number: 380843-75-4
Manufacturer Part Number/SKU: 10-2122-5mg-EA
Tags: Focus Biomolecules