BI_2536, Dual Plk/BRD4 inhibitor - Destabilizes Myc, 25mg, CAS# 755038-02-9
$275.00
4-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide Purity: 97% by HPLC Purity: NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4121-25mg-EA
BI_2536, Dual Plk/BRD4 inhibitor - Destabilizes Myc, 25mg, CAS# 755038-02-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsBI 2536 was originally reported as a potent (IC50's Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) and selective2 Polo-like kinase inhibitor (IC50's Plk1 = 0.83nM, Plk2 = 3.5nM and Plk3 = 9.0nM) that caused mitotic arrest and apoptosis induction in various human cancer cell lines.1 It was later found to be a potent inhibitor (IC50 = 100nM) of BET family member BRD4 and able to potently suppress c-Myc expression in MM.1S multiple myeloma cells.3 BI 2536 destabilizes N-Myc by inhibiting the deactivation of the ubiquitin E3 ligase Fbw7 by Plk1.4
CAS Number: 755038-02-9
Manufacturer Part Number/SKU: 10-4121-25mg-EA
Tags: Focus Biomolecules