Belumosudil, ROCK2 inhibitor, 5mg, CAS# 911417-87-3
$45.00
2-[3-[4-(1H-Indazol-5-yl)amino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4165-5mg-EA
Belumosudil, ROCK2 inhibitor, 5mg, CAS# 911417-87-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsSelective inhibitor of Rho kinase 2 (ROCK2) - IC50's: ROCK2 = 105 nM, ROCK1 = 24 µM in enzyme assays.1 It downregulated the ability of T cells to secrete IL-21 and IL-17, but not IFN-g, in response to T cell stimulation in vitro via a STAT3-dependent mechanism.2 Belumosudil ameliorated graft-versus-host disease in multiple models3,4 and was recently approved by the FDA for the treatment of GVHD (July 2021). It has also been shown to suppress adipogenesis.5-7 Suppression of adipocyte differentiation is mediated via casein kinase 2 inhibition (IC50 = 50 nM) and not ROCK2 inhibition.8
CAS Number: 911417-87-3
Manufacturer Part Number/SKU: 10-4165-5mg-EA
Tags: Focus Biomolecules