Baricitinib, JAK 1/2 inhibitor, 5mg, CAS# 1187594-09-7
$48.00
1-(Ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-3-azetidine-acetonitrile Purity: 98% by HPLC NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3893-5mg-EA
Baricitinib, JAK 1/2 inhibitor, 5mg, CAS# 1187594-09-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsBaricitinib, approved by the FDA for two inflammatory disorders, rheumatoid arthritis and alopecia areata, selectively inhibits Janus kinase 1 (IC50 = 5.9 nM) and 2 (5.7 nM), over 3 (0.56 µM).1 It thereby blocks JAK/STAT signaling, reducing cytokine release and suppressing the innate and adaptive immune systems.1,2 Was recently shown to significantly improve COVID-19 symptoms in a preliminary human trial, presumably through suppression of the cytokine release syndrome ("cytokine storm") induced by SARS-CoV-2 infection.3
CAS Number: 1187594-09-7
Manufacturer Part Number/SKU: 10-3893-5mg-EA
Tags: Focus Biomolecules