ARN25499, Cdc42 GTPase interaction inhibitor, 25mg, CAS# N/A
$275.00
N-(3,4-Dimethoxyphenyl)-4-phenyl-6-(piperidin-4-yl)pyrimidin-2-amine Purity: 99% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4412-25mg-EA
ARN25499, Cdc42 GTPase interaction inhibitor, 25mg, CAS# N/A is available to buy in increments of 1
Product Details
Download Details and SpecificationsARN25499 is a novel Cdc42 GTPase interaction inhibitor. It inhibits the interaction between Cdc42 and its downstream effectors (i.e PAK) instead of the Cdc42-GEF interaction. ARN25499 displayed activity against four melanoma cancer cell lines (IC50s: SKM28 13.5 µM, SKMeI3 8.1 µM, WM3248 12.8 µM, A375 9.7 µM) and one colon cancer line (IC50 = 11.2 µM SW480). It also displayed good pharmacokinetics in mice. ARN25499 also showed in vivo efficacy in melanoma PDX tumors in NSG mice at 10mg/kg.
Manufacturer Part Number/SKU: 10-4412-25mg-EA
Tags: Focus Biomolecules