Arecoline HBr, ACAT1 inhibitor, 250mg, CAS# 300-08-3
$30.00
1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid Purity: methyl ester Purity: hydrobromide Purity: 98% by TLC Purity: NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1016-250mg-EA
Arecoline HBr, ACAT1 inhibitor, 250mg, CAS# 300-08-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsTyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 - M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3
CAS Number: 0300-08-03
Manufacturer Part Number/SKU: 10-1016-250mg-EA
Tags: Focus Biomolecules