Alectinib, ALK inhibitor, 5mg, CAS# 1256580-46-7
$60.00
9-Ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Purity: 99% by HPLC NMr (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4793-5mg-EA
Alectinib, ALK inhibitor, 5mg, CAS# 1256580-46-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAlectinib is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET kinase (IC50 = 4.8 nM), the RET gatekeeper mutations V804L and V804M, and inhibited the growth of RET fusion positive cells.2 Alectinib is clinically useful in the treatment of ALK-positive Non-Small Cell Lung Cancer. It effectively suppressed cell proliferation and induced apoptosis in a mouse neuroblastoma xenograft.3
CAS Number: 1256580-46-7
Manufacturer Part Number/SKU: 10-4793-5mg-EA
Tags: Focus Biomolecules