AI-1, Nrf2 activator, 25mg, CAS# 75483-04-4
$280.00
4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1471-25mg-EA
AI-1, Nrf2 activator, 25mg, CAS# 75483-04-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to searve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology1. Cell permeable.
CAS Number: 75483-04-04
Manufacturer Part Number/SKU: 10-1471-25mg-EA
Tags: Focus Biomolecules