AG-490, JAK-2 inhibitor, 5mg, CAS# 133550-30-8
$50.00
(E)-2-Cyano-3-(3,4-dihydrophenyl)-N¬-(phenylmethyl)-2-propenamide Purity: 98% by TLC [ 10% methanol in methylene chloride Purity: Rf = 0.50] NMR Conforms Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1091-5mg-EA
AG-490, JAK-2 inhibitor, 5mg, CAS# 133550-30-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.
CAS Number: 133550-30-8
Manufacturer Part Number/SKU: 10-1091-5mg-EA
Tags: Focus Biomolecules