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A-769662, AMPK activator, 5mg, CAS# 844499-71-4

$72.00
4-Hydroxy-3-(2’-hydroxy-[1,1’-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-1171-5mg-EA
A-769662, AMPK activator, 5mg, CAS# 844499-71-4 is available to buy in increments of 1

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A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the b and g subunits and not the AMP binding site1. EC50=0.8 mM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 mM2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.

CAS Number: 844499-71-4

Manufacturer Part Number/SKU: 10-1171-5mg-EA

Tags: Focus Biomolecules