Manufacturer: Focus Biomolecules
A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the b and g subunits and not the AMP binding site1. EC50=0.8 mM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 mM2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.
CAS Number: 844499-71-4
Manufacturer Part Number/SKU: 10-1171-5mg-EA
Tags: Focus Biomolecules