7-Cl-O-Nec1, Rip1 blocker, 25mg, CAS# 852391-15-2
$205.00
5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione Purity: 98% by TLC (5% methanol / methylene chloride; Rf = 0.55) Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4544-25mg-EA
7-Cl-O-Nec1, Rip1 blocker, 25mg, CAS# 852391-15-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsNecrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
CAS Number: 852391-15-2
Manufacturer Part Number/SKU: 10-4544-25mg-EA
Tags: Focus Biomolecules